Li Qian and Deepak Srivastava

Deepak Srivastava: follows his heart to study the heart.

Monkeying around with cardiac progenitors: hope for the future.

Multipotent cardiovascular progenitor cells derived from ES cells or induced pluripotent stem (iPS) cells are an intriguing source for stem cell-based therapies for congenital and acquired heart diseases. From a clinical perspective, the ideal cardiac progenitor cells are those that can proliferate, survive, and differentiate into multiple mature cardiac cell types when transplanted into normal...

Direct Reprogramming of Human Fibroblasts toward a Cardiomyocyte-like State

Direct reprogramming of adult somatic cells into alternative cell types has been shown for several lineages. We previously showed that GATA4, MEF2C, and TBX5 (GMT) directly reprogrammed nonmyocyte mouse heart cells into induced cardiomyocyte-like cells (iCMs) in vitro and in vivo. However, GMT alone appears insufficient in human fibroblasts, at least in vitro. Here, we show that GMT plus ESRRG ...

miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes

Acute myocardial infarction (MI) involves necrotic and apoptotic loss of cardiomyocytes. One strategy to salvage ischemic cardiomyocytes is to modulate gene expression to promote cell survival without disturbing normal cardiac function. MicroRNAs (miRNAs) have emerged as powerful regulators of multiple cellular processes, including apoptosis, suggesting that regulation of miRNA function could s...

Expected nucleation effects of carboxylic acid salts on poly(1-butene)

9,10-Dihydro-9,10-ethano-anthracene-11,12-dicarboxylic acid disodium salt (DHEAS) was synthesized and used as a nucleating agent for poly(1-butene) (iPB). The isothermal crystallization kinetics of iPB having different nucleating agents were investigated by differential scanning calorimetry (DSC) and polarized optical microscopy (POM). The results showed that the nucleating agents increased the...